The Research
Aneuploidy is a pathological condition defined by an abnormal number of chromosomes.
The Elowe laboratory is interested in characterizing the signaling pathways and molecular mechanisms of action that ensure the precision of cell division, and thus the prevention of aneuploidy.
Precisely
Specifically, we are interested in a group of highly conserved kinases, known as the “spindle assembly checkpoint” or “SAC” kinases, which ensure normal cell division through two distinct mechanisms: Ensure the attachment of chromosomes to the cell division apparatus.
Delay the division process until all elements of the division system are in place.
Our Focus
Our research focuses on the following questions:
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What are the mechanisms of activation and inactivation of SAC kinases?
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What are the endogenous substrates of SAC kinases?
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Is SAC regulated differently in cell lines with chromosomal instability?
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How does aneuploidy contribute to cancer development?
